CORAOPOLIS, Pennsylvania -- Ed Bigley, the business manager for the Pittsburgh Plumbers Union Local 27, says the organization has been serving the region since the dawn of the industrial revolution in the 1870s, when it came under the umbrella of the Knights of Labor.By July of 1890, it had formed its own stand-alone union, even holding its first convention in the city, with the Pittsburgh Post reporting the event had a "sumptuous banquet" for the visiting delegates of plumbers from across the country as the 100 members

All prescription drugs need a licence from a regulator to treat a specific condition. But licensed drugs can be prescribed for conditions they haven’t been tested for in a clinical trial. This is known as “off-label” prescribing – and it’s very common.

The UK doesn’t have current figures on overall off-label prescribing, but a US study found that one in five prescriptions was off label.

It’s official. Joe Biden and Donald Trump have secured the necessary delegates to be their parties’ nominees for president in the 2024 election. Barring unforeseen events, the two will be formally nominated at the party conventions this summer and face off at the ballot box on Nov. 5.